MACI (autologous cultured chondrocytes on porcine collagen membrane) Skip to content

Sidelined By Knee Pain From Cartilage Damage?

Wondering what’s next for you?

Cartilage damage doesn’t heal on its own. In fact, it can get worse over time.1 See for yourself how MACI could help you overcome your knee pain. A MACI specialist will repair your knee cartilage by using your own cells to create durable repair tissue that can reduce pain*1, improve function*1, and provide lasting results†1.

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Are you ready to learn more about your knee pain?

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Get more insights into knee pain and check out the cartilage damage simulator.

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Not sure what your knee pain is telling you? Take this short quiz to see how much it affects your life.

You’ve had your initial arthroscopy.
What happens now?

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What steps should you be taking prior to your MACI procedure?

Are you and your doctor still deciding if you should move forward with MACI? Watch this video.

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Introducing a customizable app to enhance your recovery experience.

Download the My MACI App to help you prepare for your MACI procedure and to get personal guidance through your rehabilitation program.

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Download the My MACI App to help you prepare for your MACI procedure and to get personal guidance through your rehabilitation program.

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It's Your move

*In the SUMMIT clinical trial, MACI was shown to offer greater pain relief and improvement in function when compared to microfracture.
†Improvements in pain and function were maintained with MACI at year 5.
Reference: 1. Saris D, Price A, Widuchowski W, et al. Matrix-applied characterized autologous cultured chondrocytes versus microfracture: Two-year follow-up of a prospective randomized trial. Am J Sports Med. 2014;42(6):1384-94.

Indication and Important Safety Information

Important Safety Information

MACI should not be used if you:

  • are allergic to antibiotics such as gentamicin, or materials that come from cow, pig, or ox;
  • have severe osteoarthritis of the knee, other severe inflammatory conditions, infections or inflammation in the bone joint and other surrounding tissue, or blood clotting conditions;
  • have had knee surgery in the past 6 months, not including surgery for obtaining a cartilage biopsy or a surgical procedure to prepare your knee for a MACI implant;
  • or cannot follow a doctor-prescribed rehabilitation program after your surgery

Consult your doctor if you have cancer in the area of the cartilage biopsy or implant as the safety of MACI is not known in those cases.

Conditions that existed before your surgery, including meniscus tears, joint or ligament instability, or alignment problems should be evaluated and treated before or at the same time as the MACI implant.

MACI is not recommended if you are pregnant.

MACI has not been studied in patients younger than 18 or over 55 years of age.

Common side effects include joint pain, tendonitis, back pain, joint swelling, and joint effusion.

More serious side effects include joint pain, cartilage or meniscus injury, treatment failure, and osteoarthritis.

Please see Full Prescribing Information for more information.

Indication

MACI® is made up of your own (autologous) cells that are expanded and placed onto a film that is implanted into the area of the cartilage damage and absorbed back into your own tissue.

MACI® (autologous cultured chondrocytes on porcine collagen membrane) is made up of your own (autologous) cells that are expanded and placed onto a film that is implanted into the area of the cartilage damage and absorbed back into your own tissue.

MACI is used for the repair of symptomatic cartilage damage of the adult knee.

The amount of MACI applied depends on the size of the cartilage damage. The MACI film is trimmed by your surgeon to match the size and shape of the damage, to ensure the damaged area is completely covered.

Limitations of Use

It is not known whether MACI is effective in joints other than the knee.

It is not known whether MACI is safe or effective in patients over the age of 55 years.