FAQs

What makes CARTICEL different from other cartilage repair options?
Am I a candidate for CARTICEL even if I’ve undergone other treatments for knee pain? 
I am 50 years old. Will CARTICEL work for me?
How long does it take to grow the cells?
What should I expect following my surgery?
Will I need physical therapy following this surgery? 

When does physical therapy start?
What is a CPM machine?
When can I start playing sports again?

Is CARTICEL safe? Will my insurance pay for CARTICEL?
Can any surgeon treat me with CARTICEL?

What makes CARTICEL different from other cartilage repair options?

CARTICEL is the only option in cartilage repair that uses your own cultured cells to repair an articular cartilage injury in your knee. Studies have shown CARTICEL to be an effective treatment for patients who have had an inadequate response to an arthroscopic or other cartilage repair procedure.

Am I a candidate for CARTICEL even if I’ve undergone other treatments for knee pain?

Yes, CARTICEL is indicated for patients who have had an inadequate response to a prior surgical repair procedure. If you are still experiencing pain and swelling in your knee, and you are limiting your daily activities, you may be a candidate for CARTICEL. Talk to an orthopedic surgeon specifically trained in autologous chondrocyte implantation (ACI) to find out.

Am I too old for CARTICEL to work for me?

There is no age limit with CARTICEL. However, CARTICEL has not been tested in children or in patients over age 65, and CARTICEL is not indicated for treating osteoarthritis.

How long does it take to grow the cells?

After your biopsy is taken, your cells are sent to Genzyme Biosurgery for processing. It is then remains stored for up to two years or until you and your surgeon decide to go forward with the  implantation procedure. Once your surgery is scheduled, Carticel Care will work with your surgeon to ensure your cells are ready in time for your surgery, a process that takes approximately three weeks.

What should I expect following my surgery?

For the first few days, it may be hard for you to move around and you will experience some pain, which can be controlled with medication.

Will I need physical therapy following this surgery?

Yes, you will need to follow a rehabilitation program; your doctor and physical therapist will design a program for you based on the size, location, and severity of your cartilage injury.

When does physical therapy start?

Depending on your cartilage injury, you will begin using a CPM (continuous passive motion) machine within 6-24 hours of surgery. Additional therapy programs vary from patient to patient.

What is a CPM machine?

The CPM (continuous passive motion) machine allows the knee to move without engaging muscles. During recovery, using a CPM machine is important as it provides a favorable environment for the cells to grow, as well as reducing the likelihood of the knee joint becoming stiff. Studies have shown that using CPM following articular cartilage repair improves patient outcomes.1

When can I start playing sports again?

You and your doctor will decide when you are ready to return to sports. Depending on the size and location of your cartilage injury and your rehabilitation, you may resume low impact activity such as swimming, cycling, and skating as early as 6 months following treatment. You may perform higher impact sports such as jogging, running, and aerobics at 8-9 months for smaller injuries or 9-12 months for larger injuries. High impact sports such as basketball, soccer, or tennis may compromise the durability of the repair and should generally not occur until 12-18 months post-treatment. For more information, please refer to the rehabilitation page. Individual results may vary depending on what specific sport you are contemplating playing. Not all patients return to full activity.

Is CARTICEL safe?

While CARTICEL is generally safe, there are risks associated with the procedure. CARTICEL has a very low rate of complications from infection. Other complications after surgery, such as symptoms of clicking, locking, and pain, can sometimes occur. Your doctor may need to perform another surgical procedure, most often arthroscopic in nature, to remedy any issues. Subsequent surgical procedures are common, occuring in nearly half of patients. 

Will my insurance pay for CARTICEL?

Most insurance plans cover the cost of CARTICEL. Check with your plan administrator or call 800-453-6948, Option #2, to speak with a Carticel Care® Coordinator who can help you manage the approval process.

Can any surgeon treat me with CARTICEL?

Only surgeons specially trained in the implantation technique may perform the procedure. Find a CARTICEL surgeon in your area using our surgeon locator tool.

1. Salter RB. The biological concept of continuous passive motion of synovial joints: The first 18 years of basic research and its clinical application. In: Ewing JW, ed. Articular Cartilage and Knee Joint Function. New York, NY: Raven Press; 1990.

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How CARTICEL works

This animated guide explains the CARTICEL procedure.

Have Questions?

Check out our FAQs for answers—or contact a Carticel Care® Coordinator at 800-453-6948, Option #2, for more detailed information.

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Important Safety Information

CARTICEL is for autologous use and is indicated for the repair of symptomatic, cartilage defects of the femoral condyle (medial, lateral or trochlea), caused by acute or repetitive trauma, in patients who have had an inadequate response to a prior arthroscopic or other surgical repair procedure (e.g., debridement, microfracture, drilling/abrasion arthroplasty, or osteochondral allograft/autograft). CARTICEL should only be used in conjunction with debridement, placement of a periosteal flap and rehabilitation. The independent contributions of the autologous cultured chondrocytes and other components of the therapy to outcome are unknown. It is not indicated for the treatment of cartilage damage associated with generalized osteoarthritis. It is not recommended for patients whose knee meniscus has been surgically removed unless the patient has undergone surgical reconstruction prior to or concurrent with CARTICEL implantation.

Pre-existing conditions including meniscal tears, joint instability or malalignment of the joint should be corrected prior to or concurrent with CARTICEL implantation. It should not be used in patients with a known history of hypersensitivity to gentamicin, other aminoglycosides or materials of bovine origin. CARTICEL is not routinely tested for transmissible infectious diseases and may transmit disease to the healthcare provider handling CARTICEL. In addition, it should not be used in patients who have previously had cancer in the bones, cartilage, fat or muscle of the treated limb. Use in children, patients over age 65, or in joints other than the knee has not yet been assessed.

The occurrence of subsequent surgical procedures (SSPs), primarily arthroscopy, following CARTICEL implantation is common. In the Study of the Treatment of Articular Repair (STAR), forty-nine percent (49%) of patients underwent an SSP on the treated knee, irrespective of their relationship to CARTICEL, during the 4-year follow up. The most common serious adverse events (≥5% of patients), derived from STAR, include arthrofibrosis/joint adhesions, graft overgrowth, chondromalacia or chondrosis, cartilage injury, graft complication, meniscal lesion, graft delamination, and osteoarthritis.

For more information on CARTICEL, please see the Package Insert (PDF).