Brian - Age 29, Long Island, NY

When knee pain began to compromise his daily activities, Brian, a talented lawyer and sports enthusiast opted for CARTICEL to help him get back to his active lifestyle.

Brian had a CARTICEL procedure in January 2008 to repair cartilage damage in his knee. We asked Brain to share his experiences with those who had decided not to settle for limited mobility.

Q:     What activities did you enjoy before your knee injury?

A:     A lot of different sports including golf and baseball.

Q:     How did you get injured? 

A:     I stepped in a puddle at a water park and slipped, my right kneecap landed on the ground and I heard a popping sound. A few days later I went to a doctor.

Q:     What did your doctor do?

A.     He did an MRI. They thought it was just a torn meniscus but when they operated they also saw a lesion on the femur and performed a debridement on the defect. The doctor called me later and said the meniscus had been fixed, but they needed to do another procedure to repair the lesion because the debridement was not successful.

Q.     What did your doctor recommend?

A:     I’d been going to him for years, so when he recommended a CARTICEL procedure, I took his advice. He told me he had done a biopsy and that it would be grown to replace my missing articular cartilage. 

Q:     What was your biggest motivator to have the CARTICEL procedure?

A:     There was hesitation, but I knew I had to do it.  I wanted to be able to do everything that a relatively healthy young guy could do.

Q:     Was Carticel Care® helpful?   

A:     They were very reassuring. They sent me information packets so I knew what to expect. I would call them and ask a lot of questions and they were always very supportive.

Q:     What was the surgery experience like for you? 

A:     My folks accompanied me to the surgery center and I was actually relatively calm. I went into the prep room and they put a nerve block down my leg. I don’t really remember anything else until waking up.

Q:     How was your recovery immediately following the procedure? 

A:     The first week after surgery, there wasn’t a lot of pain. I still had the nerve block in for three days. I only took two or three painkillers within the first four days and then I used an over-the-counter pain reliever and the pain was tolerable. 

Q:     What did you do to prepare for your return home?

A:     I actually stayed at my parents’ house for the first part of my recovery. It made it easier to have people around to help. My parents rearranged their house so that everything I might need would be on one level. It was a great not to have to climb the stairs. 

Q:     Any rehabilitation tips for other patients? 

A:     I set goals for myself so I would realize the progress I was making. Plus I tried to keep my mind off my knee. I picked up a couple of books to teach myself a new language. 

Q:     Did you use a CPM (continuos passive motion) machine?

A:     Yes. That’s another time you felt progress in yourself. You would slowly do more, degree by degree every day. I said to myself, look at this. I am getting better and I can actually see myself getting better. It also really helped with the swelling.

Q:     How many times a week did you go to physical therapy?

A:     At first I went three times a week. After a month, it was down to two times per week. Then after six or eight weeks I also went to the gym on my own.  That was really the turning point, getting out on my own.

Q:     What kind of exercises did your physical therapist have you do?

A:     It was a lot of straight leg raises, leg presses and hamstring exercises to make sure the muscles didn’t tighten up and atrophy. I was on the exercise bike a lot, usually about a half an hour a day. We also did electric stimulation and ultrasound.

Q:     Did the surgery positively impact your life? 

A:     Definitely. Before the surgery I would get home from work and be exhausted. I wasn’t as active as I wanted to be and I took everything for granted. I’ve been so much more active since the surgery. Instead of just hanging around the house, I’m out and about doing the things I enjoy.

Q:     Is there anything you would have done differently?

A:     Absolutely. I needed more people around me. I had told my friends not to come around because I didn’t want them to see me during my recovery. I discovered the support of family and friends is really important.

Q:     What’s the best piece of advice you could give someone who’s considering a CARTICEL implant?

A:     If your doctor tells you that you need the Carticel procedure, you should research all of the websites and request brochures from the Carticel Care associates.  The websites and packets were informative, and, most importantly, eased my initial fears.

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Indications and Usage

Carticel® (autologous cultured chondrocytes) is an autologous cellular product indicated for the repair of symptomatic cartilage defects of the femoral condyle (medial, lateral or trochlea), caused by acute or repetitive trauma, in patients who have had an inadequate response to a prior arthroscopic or other surgical repair procedure (e.g., debridement, microfracture, drilling/abrasion arthroplasty, or osteochondral allograft/autograft).

CARTICEL should only be used in conjunction with debridement, placement of a periosteal flap and rehabilitation. The independent contributions of the autologous cultured chondrocytes and other components of the therapy to outcome are unknown.

CARTICEL is not indicated for the treatment of cartilage damage associated with generalized osteoarthritis.

CARTICEL is not recommended for patients with total meniscectomy unless surgically reconstructed prior to or concurrent with CARTICEL implantation.

Important Safety Information

CARTICEL should not be used in patients with a known history of hypersensitivity to gentamicin, other aminoglycosides or materials of bovine origin.

It should not be used in patients who have previously had cancer in the bones, cartilage, fat or muscle of the treated limb.

Pre-existing conditions, including meniscal tears, joint instability, or malalignment should be assessed and treated prior to or concurrent with CARTICEL implantation.

CARTICEL is not routinely tested for transmissible infectious diseases and may transmit disease to the healthcare provider handling CARTICEL.

Use of CARTICEL in children, patients over age 65, or in joints other than the knee has not yet been assessed.

The occurrence of subsequent surgical procedures (SSPs), primarily arthroscopy, following CARTICEL implantation is common. In the Study of the Treatment of Articular Repair (STAR), forty-nine percent (49%) of patients underwent an SSP on the treated knee, irrespective of their relationship to CARTICEL, during the 4-year follow up. The most common serious adverse events (≥5% of patients), derived from STAR, include arthrofibrosis/joint adhesions, graft overgrowth, chondromalacia or chondrosis, cartilage injury, graft complication, meniscal lesion, graft delamination, and osteoarthritis.

For more information on CARTICEL, please see the Package Insert (PDF).